GMP factory supply high purity Protirelin peptide CAS 24305-27-9 with DMF Plecanatide powder

1. Product Description

2. Key Specifications 

3. Mechanism of Action

• Acts as a specific agonist of thyrotropin-releasing hormone (TRH) receptors, binding to TRH receptors on the surface of anterior pituitary thyrotrophs with high affinity (EC₅₀≈1.2 μM), thereby activating the receptor signaling pathway[1][3].
• Stimulates the anterior pituitary to synthesize and secrete thyrotropin (TSH), which further promotes the synthesis and release of thyroid hormones (T3, T4) from thyroid follicular cells, regulating the hypothalamic-pituitary-thyroid (HPT) axis[1][5].
• Beyond endocrine regulation, it also acts on TRH receptors in the central nervous system (CNS), promoting the secretion of prolactin and oxytocin, regulating sleep-wake cycles, mood, and cognitive function, with potential antidepressant and neuroprotective effects[1][5].
• Activates the phospholipase C (PLC) signaling pathway, increasing intracellular calcium ion (Ca²⁺) concentration and inositol triphosphate (IP3) levels, which serves as a second messenger to mediate its physiological effects[1][3].
• Exhibits high metabolic stability in vitro and in vivo, with a plasma half-life of approximately 4–6 minutes in humans, rapidly metabolized by TRH-degrading enzymes in the liver and kidneys[1][3].
• Regulates thyroid function homeostasis, and can be used to evaluate pituitary-thyroid axis function by detecting TSH response after administration[1][5].

4. Main Applications

• Pharmaceutical API: Used in the R&D and production of injectable preparations for the diagnosis and treatment of thyroid function disorders, such as hypothyroidism, pituitary hypofunction, and thyroid cancer, as well as the evaluation of pituitary-thyroid axis function[1][5].
• Research & Development: Applied in preclinical pharmacology, toxicology, and formulation optimization studies related to thyroid disorders, central nervous system diseases, and hypothalamic-pituitary axis regulation[1][3].
• Scientific Research: Suitable for laboratory studies on thyroid hormone regulation, TRH receptor signaling pathways, neuroendocrine interactions, and the development of novel TRH agonists/antagonists[1][5].
• Biomedical Research: Used in studies on depression, sleep disorders, cognitive impairment, and thyroid-related autoimmune diseases, as well as high-throughput screening of drugs targeting the HPT axis[1][3].

5. Our Advantages

• Ultra-High Purity: HPLC ≥98.0%, strict control of impurities, ensuring high biological activity and safety for pharmaceutical R&D and formulation[3][5].
• Stable Tripeptide Structure: Produced via advanced solid-phase synthesis technology, ensuring the stability of the pyroglutamyl structure and optimal binding affinity to TRH receptors[1].
• Stable Quality: Strict production process control and comprehensive analytical testing (COA, HPLC, MS, NMR) provided for each batch, ensuring batch-to-batch consistency[3][5].
• Professional Manufacturing: Produced in a GMP-compliant cleanroom with strict contamination control, meeting international pharmaceutical and research standards[3][5].
• Excel-Exportable Specifications: The key specifications table can be directly copied to Excel, facilitating your product management and customer communication.
• Complete Documentation: Full technical dossiers, including COA, MSDS, stability data, and analytical reports, available upon request to support global regulatory filings[3][5].

6. Storage & Handling

• Storage: Store at ≤ -20°C, protected from light, heat, and moisture; keep desiccated in a dark place to avoid degradation[2][3]. Shelf life is 2 years under proper storage conditions; shelf life at -80°C is extended to 3 years[2].
• Transport: Transport with dry ice or professional cold-chain packaging to maintain low-temperature stability; short-term ambient temperature transport (≤24 hours) is acceptable[2].
• Reconstituted Solution: Use within 2 weeks if stored at 2–8°C, and within 3 months if stored at -20°C; avoid repeated freeze-thaw cycles[2].
• Avoid repeated freeze-thaw cycles, as this may affect peptide activity and biological potency[2][3].
• Handling: Wear protective gloves, clothing, and goggles; operate in a well-ventilated area to avoid inhalation and skin/eye contact[3][5].

7. Safety & Compliance Notice

• For research and industrial manufacturing use only.
• Not for direct human or animal administration; intended for pharmaceutical formulation, laboratory research, or R&D use only[3][5].
• Strictly comply with local laws and regulations regarding peptide APIs, pharmaceutical raw materials, and controlled substances; Protirelin is a prescription-only drug in most jurisdictions[5]. It is contraindicated in patients with hyperthyroidism and hypersensitivity to any component of the product[5].
• Full MSDS (Material Safety Data Sheet) with detailed safety information, including adverse effects (e.g., headache, nausea, flushing, transient hyperthyroidism symptoms) and handling precautions, is provided with each order[4][5].

8. Packaging & Shipping

• Packing: 0.1g, 0.5g, 1g, 5g, 10g, 100g sealed lyophilized vials or aluminum foil bags; customizable packaging available based on order quantity[3][5].
• MOQ: Flexible, supporting small-batch R&D orders and large-scale bulk orders.
• Lead Time: In-stock items shipped within 2–3 working days; custom orders negotiated based on quantity.
• Shipping: Cold-chain transport via DHL, FedEx, UPS, or international air/sea freight, with full tracking provided to ensure safe delivery[3][5].