GMP factory supply high purity Plecanatide peptide CAS 467426-54-6 with DMF Plecanatide powder

1. Product Description

2.

3. Mechanism of Action

• Acts as a potent agonist of guanylate cyclase-C (GC-C) receptors, specifically binding to the luminal side of GC-C receptors on intestinal epithelial cells (a member of the GPCR family) with high affinity (EC₅₀≈0.3 μM)[1][2].
• Activates GC-C receptors to catalyze the conversion of GTP to cyclic guanosine monophosphate (cGMP), significantly increasing intracellular cGMP concentrations, which acts as a second messenger to activate protein kinase G II (PKG-II)[1].
• PKG-II phosphorylates and opens cystic fibrosis transmembrane conductance regulator (CFTR) channels, mediating the active secretion of Cl⁻ and HCO₃⁻ into the intestinal lumen, increasing intestinal osmotic pressure and promoting passive water entry into the intestinal lumen[1].
• Softens feces and accelerates intestinal peristalsis, thereby relieving constipation symptoms; it acts locally in the intestine with almost no absorption into the bloodstream, avoiding the risk of systemic cGMP elevation[1][4].
• Exhibits pH-dependent activity, with the strongest activity in the acidic intestinal environment (pH 5–6), preferentially acting on the small intestine and proximal colon to precisely regulate intestinal secretion[1].
• Enhances intestinal barrier function by upregulating tight junction proteins (occludin, ZO-1), reducing intestinal leakage and the release of inflammatory factors, with dual effects of promoting secretion and protecting the intestine[1].

4. Main Applications

• Pharmaceutical API: Used in the R&D and production of oral preparations for the treatment of adult chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C), improving defecation frequency and fecal properties[1][4].
• Research & Development: Applied in preclinical pharmacology, toxicology, and formulation optimization studies related to constipation, intestinal functional disorders, and GC-C/CFTR/cGMP signaling pathways[1][2].
• Scientific Research: Suitable for laboratory studies on intestinal ion transport, intestinal barrier function, constipation pathogenesis, and the development of novel anti-constipation therapeutics[1][3].
• Biomedical Research: Used in studies on opioid-induced constipation (OIC), diabetic constipation, and inflammatory bowel disease (IBD) complicated with constipation, as well as high-throughput screening of GC-C agonists/antagonists[1].

5. Our Advantages

• Ultra-High Purity: HPLC ≥98.0%, strict control of impurities, ensuring high biological activity and safety for pharmaceutical R&D and formulation[3][5].
• Stable Cyclic Structure: Produced via advanced microwave-assisted solid-phase synthesis and traceless cyclization technology, ensuring the stability of disulfide bridges and optimal binding affinity to GC-C receptors[1].
• Stable Quality: Strict production process control and comprehensive analytical testing (COA, HPLC, MS, NMR) provided for each batch, ensuring batch-to-batch consistency[3][5].
• Professional Manufacturing: Produced in a GMP-compliant cleanroom with strict contamination control, meeting international pharmaceutical and research standards[3][5].
• Excel-Exportable Specifications: The key specifications table can be directly copied to Excel, facilitating your product management and customer communication.
• Complete Documentation: Full technical dossiers, including COA, MSDS, stability data, and analytical reports, available upon request to support global regulatory filings[3][5].

6. Storage & Handling

• Storage: Store at ≤ -20°C, protected from light, heat, and moisture; keep desiccated in a dark place to avoid degradation[2][3]. Shelf life is 2 years under proper storage conditions; shelf life at -80°C is extended to 2 years[2].
• Transport: Transport with dry ice or professional cold-chain packaging to maintain low-temperature stability; short-term ambient temperature transport is acceptable in continental US[2].
• Reconstituted Solution: Use within 1 month if stored at -20°C, and within 6 months if stored at -80°C; avoid repeated freeze-thaw cycles[2].
• Avoid repeated freeze-thaw cycles, as this may affect peptide activity and biological potency[2][3].
• Handling: Wear protective gloves, clothing, and goggles; operate in a well-ventilated area to avoid inhalation and skin/eye contact[3][5].

7. Safety & Compliance Notice

• For research and industrial manufacturing use only.
• Not for direct human or animal administration; intended for pharmaceutical formulation, laboratory research, or R&D use only[3][4].
• Strictly comply with local laws and regulations regarding peptide APIs, pharmaceutical raw materials, and controlled substances; Plecanatide is a prescription-only drug in most jurisdictions[4]. It is contraindicated in patients with mechanical intestinal obstruction and children under 6 years old[4].
• Full MSDS (Material Safety Data Sheet) with detailed safety information, including adverse effects (e.g., diarrhea, abdominal distension, nausea) and handling precautions, is provided with each order[4][5].

8. Packaging & Shipping

• Packing: 0.1g, 0.5g, 1g, 5g, 10g, 100g sealed lyophilized vials or aluminum foil bags; customizable packaging available based on order quantity[3][5].
• MOQ: Flexible, supporting small-batch R&D orders and large-scale bulk orders.
• Lead Time: In-stock items shipped within 2–3 working days; custom orders negotiated based on quantity.
• Shipping: Cold-chain transport via DHL, FedEx, UPS, or international air/sea freight, with full tracking provided to ensure safe delivery[3][5].