Résumé du produit
Tropisetron Hydrochloride (CAS 105826-92-4) Product Details Tropisetron Hydrochloride, with CAS Number 105826-92-4, is a highly selective and potent 5-HT3 receptor antagonist, also known as SDZ-ICS-930, ICS 205-930 or Navoban®. It belongs to the indole derivative class, specifically the endo-8...
GMP Standard Tropisetron hydrochloride CAS 105826-92-4 Tropisetron Powder 99% Purity Under CDE
Propriétés de base
Lieu d'origine:
Chine
Nom de la marque:
Bovita
Attestation:
ISO/GMP
Numéro de modèle:
BVTC02
Propriétés commerciales
Quantité minimum de commande:
5g
Prix:
50usd/g
Emballage standard:
10g/sac de papier d'aluminium
Conditions de paiement:
LC, D/A, D/P, T/T, Western Union
Capacité d'approvisionnement:
10kg/mois
Détails de produit
Mettre en évidence:
GMP Standard Tropisetron hydrochloride powder
,Tropisetron hydrochloride 99% purity
,CDE approved Tropisetron powder
Shelflife:
24 à 36 mois
Color:
Poudre blanche
Storageconditions:
Conserver dans un endroit frais et sec, à l'abri de la lumière du soleil
CAS:
105826-92-4
Delivery:
3-5 jours
Payment Terms:
T/T, DP/DA/LC/union occidentale
Description de produit
Spécifications détaillées et caractéristiques
Tropisetron Hydrochloride (CAS 105826-92-4) Product Details
Tropisetron Hydrochloride, with CAS Number 105826-92-4, is a highly selective and potent 5-HT3 receptor antagonist, also known as SDZ-ICS-930, ICS 205-930 or Navoban®. It belongs to the indole derivative class, specifically the endo-8-methyl-8-azabicyclo(3.2.1)octan-3-yl 1H-indole-3-carboxylate hydrochloride, and exhibits strong antiemetic, neuroprotective and immunomodulatory properties. As a high-purity pharmaceutical raw material, it strictly complies with international pharmaceutical standards (GMP, USP, EP) and is widely used in global medical practice, clinical trials and pharmaceutical R&D, especially for chemotherapy-induced nausea and vomiting (CINV) treatment and related drug development.
Product Basic Information
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Item
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Details
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CAS Number
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105826-92-4
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Product Name
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Tropisetron Hydrochloride; Tropisetron HCl; SDZ-ICS-930; ICS 205-930; Navoban® (marketed brand)
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Chemical Formula
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C₁₇H₂₀N₂O₂·HCl; C₁₇H₂₁ClN₂O₂
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Molecular Weight
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Approx. 320.81
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Appearance
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White to Light Yellow Crystalline Powder
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Purity
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≥98% (HPLC); ≥99% available for medical grade; Single impurity ≤1%
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Solubility
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Water: >10 mg/mL; DMSO: >35 mg/mL; Soluble in methanol; Insoluble in non-polar solvents; Ultrasonic assistance recommended for better dissolution
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Storage Condition
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Sealed, Protected from Light and Moisture; 2-8°C for long-term storage (2 years); Room temperature stable for short-term shipping (several days); Avoid heat and extreme temperature changes
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Shelf Life
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24 Months under Proper Storage Conditions (powder)
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Key Identifiers
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EINECS: 630-417-9; MDL Number: MFCD00210221; ATC Code: A04AA03; RTECS Number: NL6012520; Melting Point: 283-285°C (dec.)
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Pharmacological Action & Clinical Applications
Mechanism of Action
Tropisetron Hydrochloride acts as a selective, competitive antagonist of the 5-hydroxytryptamine type 3 (5-HT3) receptor (IC50 = 70.1 nM), blocking serotonin action both peripherally on vagus nerve terminals in the gastrointestinal tract and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, the emetic center of the brain. It also functions as an α7-nicotinic acetylcholine receptor (α7-nAChR) agonist and calmodulin inhibitor, exerting neuroprotective and immunomodulatory effects. Unlike some antiemetics, it has minimal affinity for other receptors (5-HT1, 5-HT2, dopamine, histamine), resulting in fewer extrapyramidal side effects. It is mainly metabolized by cytochrome P450 (CYP) 2D6 in the human body, with a half-life of approximately 8-10 hours.
Main Clinical Uses
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Antiemetic Therapy: First-line treatment for chemotherapy-induced nausea and vomiting (CINV) and radiotherapy-induced nausea and vomiting; also used for postoperative nausea and vomiting (PONV) prophylaxis and treatment, effectively reducing the incidence of acute and delayed emesis.
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Neuroprotection: Exhibits neuroprotective effects against glutamate-induced excitotoxicity (EC50 = 62 nM) in retinal ganglion cells; studied for potential application in neurodegenerative disease research, such as Alzheimer's disease and Parkinson's disease.
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Immunomodulation: Inhibits IL-2 gene transcription and synthesis in stimulated T cells; studied for inflammatory and autoimmune disease research, providing a new direction for the treatment of related diseases.
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Pharmaceutical R&D: Key raw material for the production of oral and injectable dosage forms; tool compound for 5-HT3 receptor and α7-nAChR pathway research, facilitating the development of new antiemetic and neuroprotective drugs.
Contraindications & Adverse Reactions
Contraindications: Prohibited for patients with hypersensitivity to tropisetron or any component of the product; patients with severe hepatic impairment; pregnant and lactating women; and children under 2 years old.
Adverse Reactions: Well-tolerated with mild and transient side effects. Common reactions include headache, constipation, dizziness, fatigue, insomnia and dry mouth. Rare reactions include diarrhea, abdominal pain, transient elevation of liver enzymes, hypotension, skin rashes and pruritus. Extrapyramidal symptoms are extremely rare, which is a significant advantage compared with other antiemetic drugs.
Export Compliance & Trade Information
Regulatory Attribute
Tropisetron Hydrochloride is classified as a pharmaceutical raw material (antiemetic drug) in China, subject to the administration of Drug Import and Export License (Regulatory Code: L). It complies with GMP, USP, EP and other international pharmaceutical standards, and is included in the WHO Essential Medicines List. It is a prescription drug in most countries and regions around the world, not a controlled substance, but requires strict compliance with local pharmaceutical regulatory requirements.
HS Code & Declaration Elements
Recommended HS Code: 2934999090 (Other heterocyclic compounds; subject to the latest customs code of the importing country); For finished dosage forms, refer to HS Code 3004 (Medicaments for therapeutic or prophylactic uses). Note that ECCN (Export Control Classification Number) should be confirmed based on local regulations for US exports, and the recommended HS Code for some regions is 2933.99.7500.
Declaration Elements: CAS Number, Product Name, Purity, Usage (Medical/Pharmaceutical R&D), Composition, Brand, Chemical Formula, ATC Code, UN Number (UN2811), Hazard Class (6.1, III), Melting Point, etc.
Export Documentation Requirements
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Drug Export Sales Certificate (valid for 3 years), issued by the provincial drug regulatory authority of China.
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Import License or official certification of the importing country (if required), especially complying with FDA regulations for the US market and EMA requirements for the EU market (including CEP certification if applicable).
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Relevant qualifications: GMP Certificate, Production Approval Number, Sales Contract, Certificate of Origin, etc.
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Test Reports: COA (Certificate of Analysis), MSDS (Material Safety Data Sheet), purity test report (HPLC), melting point test report (283-285°C), heavy metal test report (≤10ppm, available upon request), and NMR structure verification report.
Logistics & Packaging
Packaging: Aluminum foil bags or glass vials, labeled with "Pharmaceutical Raw Material, Protect from Light, Keep Dry", chemical formula, storage conditions and GHS classification information (Signal Word: Danger; Hazard Statement: H301); sealed packaging to prevent moisture, contamination and degradation. Vacuum-packed options are available upon request. Labeling should comply with local pharmaceutical packaging regulations and GHS requirements.
Transportation: Ambient temperature shipping is acceptable for short-distance transportation (stable at room temperature for several days during shipping and customs clearance); cold chain transportation (2-8°C, shipping with blue ice) is recommended for long-distance or high-temperature environments to ensure product quality. It belongs to hazardous material with UN Number 2811, Hazard Class 6.1, Packing Group III, and must comply with relevant hazardous material transportation regulations.
Quality Assurance & After-Sales Service
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Strict Quality Control: Each batch of products undergoes HPLC, MS, NMR and melting point verification tests to ensure purity, stability and chemical structure accuracy; heavy metal, residue and microbial tests are available upon request. Product quality meets USP, EP and CP standards, with purity ≥98% for research grade and ≥99% for medical grade.
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Customized Service: We can provide customized packaging and specifications according to customer needs, including small-volume research-grade products (≥98% purity) and large-volume pharmaceutical-grade products (≥99% purity), as well as customized technical support for dosage form development and solubility guidance.
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After-Sales Support: Provide professional technical guidance (including reconstitution, storage and formulation guidance), timely solve logistics and customs clearance problems, and ensure smooth trade; provide relevant regulatory compliance guidance for specific markets (such as FDA registration guidance and EU CEP certification guidance).
Notation globale
cinq étoiles
100%
4 étoiles
0
3 étoiles
0
2 étoiles
0
1 étoile
0
Toutes les critiques
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Mgood quality, mainly is double customs clearance, i not do anything.
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MI sell many in Europe, nice
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MVery good price, helped my business
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