製品概要
Apraglutide (CAS 1295353-98-8) Product Details Apraglutide, with CAS Number 1295353-98-8, is a synthetic, long-acting glucagon-like peptide-2 (GLP-2) agonist, also known as FE 203799. It is a 33-amino acid modified peptide with four amino acid substitutions compared to the native GLP-2, which ...
GMP factory supply high purity Apraglutide peptide CAS 1295353-98-8 Apraglutide powder for research
基本プロパティ
取引物件
GMP Apraglutide peptide powder
,high purity Apraglutide CAS 1295353-98-8
,research-grade Apraglutide peptide
Product Basic Information
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Item
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Details
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CAS Number
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1295353-98-8
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Product Name
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Apraglutide; FE 203799; GLP-2 Analogue
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Chemical Formula
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C₁₇₂H₂₆₃N₄₃O₅₂
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Molecular Weight
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Approx. 3765.24
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Appearance
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White to Off-White Solid Powder
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Purity
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≥98% (HPLC); ≥99% available for research grade
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Solubility
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DMSO: ~100 mg/mL (26.56 mM, ultrasonic assistance recommended); Insoluble in Water; Homogeneous suspension in CMC-Na (≥5 mg/mL)
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Storage Condition
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Sealed, Protected from Light; Powder: -20°C for 3 years, 4°C for 2 years; Dissolved: -80°C for 6 months, -20°C for 1 month; Avoid repeated freeze-thaw cycles and moisture exposure
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Shelf Life
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36 Months under Proper Storage Conditions (powder)
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Peptide Sequence
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His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Nle-D-Phe-Thr-Ile-Leu-Asp-Leu-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-NH₂ (HGDGSFSDE-Nle-d-F-TILDLLAARDFINWLIQTKITD-NH₂)
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Pharmacological Action & Clinical Applications
Mechanism of Action
Main Clinical Uses
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Intestinal Disorder Research: Primarily studied for the treatment of short bowel syndrome (SBS), especially short bowel syndrome with intestinal failure (SBS-IF), helping reduce patients’ dependence on parenteral (intravenous) nutrition by improving intestinal absorption capacity.
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Graft-Versus-Host Disease (GVHD) Research: Investigated for the prevention and treatment of gastrointestinal GVHD, a complication of bone marrow or stem cell transplantation, by enhancing intestinal barrier function and reducing intestinal inflammation.
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Pharmaceutical R&D: Serves as a key tool for researching the GLP-2 receptor pathway and developing new drugs for intestinal disorders, with ongoing clinical trials evaluating its safety, efficacy, and pharmacokinetics in different patient populations.
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Animal Model Research: Widely used in animal experiments (e.g., neonatal piglet models of SBS with total ileal resection) to study intestinal adaptation and linear intestinal growth, providing a basis for clinical application research.
Contraindications & Adverse Reactions
Export Compliance & Trade Information
Regulatory Attribute
HS Code & Declaration Elements
Export Documentation Requirements
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Drug Export Sales Certificate (valid for 3 years), issued by the provincial drug regulatory authority of China.
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Import License or official certification of the importing country (if required), especially complying with FDA regulations for the US market, CEP requirements for the EU market, and EAR requirements for US exports, as well as orphan drug related certifications.
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Relevant qualifications: GMP Certificate, Production Approval Number, Sales Contract, etc.
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Test Reports: COA (Certificate of Analysis), MSDS (Material Safety Data Sheet), peptide sequence verification report, purity test report (HPLC/MS), and endotoxin test report (available upon request).
Logistics & Packaging
Quality Assurance & After-Sales Service
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Strict Quality Control: Each batch of products undergoes HPLC, MS and peptide sequence verification tests to ensure purity, stability and structural accuracy; endotoxin testing (≤50EU/mg) is available upon request. Single impurity ≤2% and peptide content ≥75.0% are guaranteed for research and medical grade products.
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Customized Service: We can provide customized packaging and specifications according to customer needs, including small-volume research-grade products (≥99% purity) and large-volume medical-grade products, as well as customized solvent formulation guidance for in vivo and in vitro use.
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