GMP factory supply bulevirtide peptide powder cas 2012558-47-1 purity 99%

Bulevirtide Peptide Powder (CAS 2012558-47-1)

Bulevirtide (also known as Myrcludex B or Hepcludex) is a first-in-class linear lipopeptide consisting of 47 amino acids with an N-terminal myristoylation group. This lyophilized powder is a synthetic derivative of the hepatitis B virus (HBV) pre-S1 domain, designed to target the sodium-taurocholate co-transporting polypeptide (NTCP) receptor, the key entry receptor for both HBV and hepatitis delta virus (HDV) in hepatocytes.
Key Specifications

CAS Number    2012558-47-1
Molecular Formula    C₂₄₈H₃₅₅N₆₅O₇₂
Molecular Weight    5398.91 Da
Purity    ≥98%–99.8% (HPLC)
Appearance    White to off-white lyophilized powder
Solubility    Soluble in 50% acetic acid (1 mg/mL); sparingly soluble in water
Storage    -20°C (desiccated); -80°C for long-term storage
Sequence    Myr-Gly-Thr-Asn-Leu-Ser-Val-Pro-Asn-Pro-Leu-Gly-Phe-Phe-Pro-Asp-His-Gln-Leu-Asp-Pro-Ala-Phe-Gly-Ala-Asn-Ser-Asn-Asn-Pro-Asp-Trp-Asp-Phe-Asn-Pro-Asn-Lys-Asp-His-Trp-Pro-Glu-Ala-Asn-Lys-Val-Gly-NH₂

Bulevirtide acts as a high-affinity NTCP inhibitor (IC₅₀ ≈ 80–140 pM):
Viral Entry Blockade: Binds specifically to NTCP on hepatocytes, competitively inhibiting HBV and HDV attachment and entry.
Antiviral Potency: Suppresses HBV/HDV infection at sub-nanomolar concentrations, preventing viral replication and spread.
NTCP Modulation: Inactivates NTCP function without significantly impairing bile salt transport at therapeutic doses.

Applications
Antiviral Research: Essential for studying HBV/HDV entry mechanisms, viral-host interactions, and NTCP biology.
 Development: Preclinical and clinical development for chronic hepatitis D (HDV) infection, often in combination with HBV nucleoside analogs.
Liver Disease Research: Investigations into compensated cirrhosis, viral hepatitis co-infections, and hepatocyte receptor function.
Biomedical Assays: Positive control for NTCP inhibition assays and HBV/HDV entry inhibition studies.

Quality Assurance
Manufactured under GMP-compliant facilities with rigorous quality control.
Validated by HPLC, Mass Spectrometry (MS), and Amino Acid Analysis for identity, purity, and sequence accuracy.
Supplied with Certificate of Analysis (COA) and Safety Data Sheet (SDS).

Why Choose Our Bulevirtide?
Ultra-High Purity: ≥98% HPLC grade ensures consistent, reproducible antiviral activity.
Verified Bioactivity: Potent NTCP inhibition confirmed in cell-based assays.
Custom Packaging: Available in 1mg, 5mg, 10mg, and bulk quantities to suit research and production needs.
Global Shipping: Fast, cold-chain delivery to research institutions and pharmaceutical companies worldwide.
Order Information
Product Name: Bulevirtide Peptide Powder
CAS: 2012558-47-1
Purity: ≥98% (HPLC)
Form: Lyophilized Powder