Product Summary
GMP factory sale High Purity Difelikefalin peptide powder cas 1024828-77-0 Difelikefalin peptide with DMF Difelikefalin peptide powder, CAS 1024828-77-0, high-purity CR845, research-grade KOR agonist, difelikefalin for pruritus research, peripheral opioid peptide, lyophilized difelikefalin ...
GMP factory sale High Purity Difelikefalin peptide powder cas 1024828-77-0 Difelikefalin peptide with DMF
Basic Properties
Trading Properties
GMP Difelikefalin peptide powder
,High purity Difelikefalin powder
,Difelikefalin peptide with DMF
GMP factory sale High Purity Difelikefalin peptide powder cas 1024828-77-0 Difelikefalin peptide with DMF
Difelikefalin peptide powder, CAS 1024828-77-0, high-purity CR845, research-grade KOR agonist, difelikefalin for pruritus research, peripheral opioid peptide, lyophilized difelikefalin
Difelikefalin (CAS 1024828-77-0), also known as CR845, FE-202845, and Korsuva™, is a synthetic, peripherally selective κ-opioid receptor (KOR) agonist. It acts by binding to peripheral KORs to modulate pruritus, inflammatory signals, and pain without significant central nervous system penetration, avoiding central adverse effects like respiratory depression. This tetrapeptide is a key research tool for studying itch mechanisms, neuro-immune interactions, and analgesic development.
| Parameter | Specification |
|---|---|
| Chemical Name | Difelikefalin (Free Base) |
| CAS Number | 1024828-77-0 |
| Molecular Formula | C₃₆H₅₃N₇O₆ |
| Molecular Weight | ~679.85 g/mol |
| Purity | ≥98.0% (HPLC), with single impurity ≤1.0% |
| Appearance | White to off-white lyophilized powder |
| Solubility | Water ≥100 mg/mL; DMSO ≥90 mg/mL |
| Storage | -20°C, sealed, dry, protected from light |
| Shelf Life | 2 years at -20°C; 1 year at -20°C (open); 6 months/-1 month in solvent at -80°C/-20°C |
Key Features & Advantages
- Peripheral Selectivity: Limited blood-brain barrier penetration minimizes central side effects.
- High Potency & Selectivity: Targets KORs with minimal cross-reactivity to other opioid receptors.
- Rigorous QC: HPLC, LC-MS, and NMR confirmation for batch consistency.
- Low Endotoxin: ≤1000 EU/mg (standard for research-grade peptides).
- Flexible Packaging: Available in mg to g scales with custom vial options.
Research Applications
- Pruritus Research: Investigating uremic pruritus in hemodialysis patients and chronic itch mechanisms.
- Pain & Inflammation: Studying peripheral analgesia and anti-inflammatory pathways in post-op and chronic pain models.
- Neuro-Immunology: Exploring KOR-mediated immune cell modulation and neuroinflammation.
- Pharmaceutical R&D: Reference standard for formulation, bioactivity, and safety profiling.
- Neuroscience: Analyzing peripheral opioid signaling and sensory neuron function.
Quality Control & Documentation
- HPLC purity & identity verification
- LC-MS molecular confirmation
- ¹H-NMR structural consistency
- Endotoxin, heavy metal, and microbial limits testing
- Full COA, SDS, and batch traceability (available on request)
Handling & Storage
- For Research Use Only. Not for human/veterinary clinical use.
- Store lyophilized powder at -20°C upon receipt; aliquot to avoid freeze-thaw cycles.
- Ship ambient for short durations; maintain cold chain for long-term transport.
Synonyms
Shipping & Logistics
- Global express delivery with temperature-controlled packaging.
- In-stock orders ship within 24–48 hours; discreet, secure packaging for customs compliance.
Compliance
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SI have bought 3 times, very good
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Agood quality, safety shipment
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